sulpiride-induced hyperprolactinemia in mature female rats: evidence for alterations in the reproductive system, pituitary and ovarian hormones

Sulpiride-Induced Hyperprolactinemia in Mature Female Rats: Evidence for Alterations in The Reproductive System, Pituitary and Ovarian Hormones

Sulpiride-Induced Hyperprolactinemia in Mature Female Rats: Evidence for Alterations in The Reproductive System, Pituitary and Ovarian Hormones

BACKGROUND The prevalence of hyperprolactinemia following administration of conven- tional antipsychotic drugs requires further investigation. The current study is designed to evaluate the effect of sulpiride (SPD)-induced hyperprolactinemia on alterations to ovarian follicular growth, gonadotropins, and ovarian hormones and to analyze the extent of potential problems in mammary glands. MATER...

P-50: The Effect of Sulpiride on Reproductive System in Female Rats

Background: Sulpiride is a substituted benzamide derivative and a selective dopamine D2 antagonist with antipsychotic and antidepressant activity. Sulpiride is effective in the treatment of acute and chronic schizophrenia.Sexual function is multifaceted and is affected in many ways by schizophrenia and the antipsychotic drugs used in its treatment . Sulpiride are associated with elevation of pr...

Effects of Carthamus tinctorius L. on the ovarian histomorphology and the female reproductive hormones in mice

Objective: Carthamus tinctorius L. (Safflower) is a member of the asteraceae family which had been classified as a fertility regulator in the traditional medicine. The purpose of this study was to investigate its possible effects on the ovarian histomorphology and the levels of female reproductive hormones in the mice. Materials and Methods: Sixty adult female Balb/C mice were selected and rand...

Curcumin and Quercetin Ameliorated Cypermethrin and Deltamethrin-Induced Reproductive System Impairment in Male Wistar Rats by Upregulating The Activity of Pituitary-Gonadal Hormones and Steroidogenic Enzymes

Objective Indiscriminate use of synthetic pyrethroid insecticides, Cypermethrin (Cyp) and Deltamethrin (Del) have been reported to cause system toxicity in mammals including humans. The dietary antioxidants protects tissues and organs against insecticides/xenobiotic induced damage. In present study, we evaluated the effect of exposure of Cyp and Del and possible protective roles of curcumin and...

The effect of Hydro-alcoholic extract of pumpkin seeds on Oogenesis and Hormone-Pituitary-Ovarian Axis in Mature Rats

Introduction: In traditional medicine, pumpkin seeds are prescribed and used commonly as energetic and sexual enhancer substances. This study was planned and carried out in order to fill the gap caused by the lack of sufficient scientific evidence on the effect of this substance on oogenesis and hormone-pituitary-ovarian axis. Revealing the effect of hydro-alcoholic extract of pumpkin seeds on ...